NSAIDs also cause an increased risk of serious gastrointestinal (GI) adverse events, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal.
Diclofenac sodium is contraindicated in the setting of coronary artery bypass graft surgery. NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Oral route (Tablet; Capsule, Liquid Filled; Powder for Solution) NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal.
Diclofenac is contraindicated in the setting of coronary artery bypass graft surgery. NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Continuing ringing or buzzing or other unexplained noise in the ears excess air or gas in the stomach or intestines hearing loss lack or loss of strength passing gas NSAIDs including this drug, can cause serious gastrointestinal (GI) events which can occur at any time, with or without warning.
Patients with a prior history of peptic ulcer disease and/or GI bleeding had a greater than 10-fold increased risk for developing a GI bleed than patients with neither of these risk factors. Elevations to greater than 3 x URN of AST occurred in about 2% (n=5700) of patients at some point during treatment.
NSAIDs inhibit platelet aggregation and have been shown to prolong bleeding time in some patients. Unlike aspirin, the NSAID effect on platelet function is quantitatively less, of shorter duration, and reversible.
Frequency not reported : Confusion, drowsiness, insomnia, paresthesia, tremors Clinical trials of several cyclooxygenase (COX)-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal.
Pharmacoepidemiological data reveal an increased risk of arteriothrombotic events associated with diclofenac (the active ingredient contained in Voltaren) use, particularly at a high dose and during long-term treatment. In a meta-analysis of long-term treatment with diclofenac 150 mg/day, compared with placebo use of this drug resulted in approximately 3 additional major vascular events per 1000 participants.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Diclofenac helps to relieve pain and inflammation by blocking the effects of cyclooxygenase (COX) enzymes.
Voltaren belongs to a class of medicines known as NSAIDs (non-steroidal anti-inflammatory drugs). Used to relieve mild-to-moderate acute pain associated with osteoarthritis and rheumatoid arthritis.
People of an older age, taking other medicines that affect the stomach, or who drink more than 3 glasses of alcohol per day may be more at risk. Other side effects including tinnitus (ringing in the ears) have also been reported.
Most NSAIDs have been associated with an increased risk of serious cardiovascular events including stroke or heart attack. May increase bleeding time especially if given with other medicines that also delay blood clotting.
May interact with some other medicines such as warfarin, SSRIs, ACE inhibitors, and diuretics. Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects.
Taking Voltaren with food may help with stomach-related side effects. Time to peak effect varies from 30 minutes to 3-5 hours depending on the formulation of Voltaren taken.
ACE inhibitors or Arms, such as captopril, enalapril, or losartan antibiotics, such as ciprofloxacin or vancomycin anticoagulants (blood thinners) such as apixaban, dabigatran, fondaparinux, heparin, or warfarin antidepressants, such as citalopram, Escitalopram, fluoxetine, or fluoxetine antifungals, such as voriconazole beta blockers, such as acebutolol, atenolol, bisoprolol, or carvedilol bisphosphonates, such as alendronate diuretics (water pills), such as chlorthalidone, chlorothiazide, or hydrochlorothiazide HIV medications (e.g., Sterile, tenofovir) other non-steroidal anti-inflammatories (NSAIDs), such as celecoxib, eidola, ibuprofen, Motorola, meloxicam, nabumetone, or naproxen sulfonylureas (a type of diabetes medication), such as glimepiride, glyceride, or glipizide supplements, such as glucosamine, omega-3 fatty acids, vitamin E others, such as cyclosporine, lithium, methotrexate, penetrated, pirfenidone, or tacrolimus. Drinking alcohol while taking Voltaren may increase the risk of gastrointestinal-related side effects or kidney damage.
Note that this list is not all-inclusive and includes only common medications that may interact with Voltaren. You should refer to the prescribing information for Voltaren for a complete list of interactions.
Diclofenac works by reducing substances in the body that cause pain and inflammation. Voltaren gel is used to treat osteoarthritis of the knees and hands.
You should not use Voltaren if you have a history of allergic reaction to aspirin or NSAIDs (non-steroidal anti-inflammatory drugs). Voltaren increase your risk of fatal heart attack or stroke.
These conditions can occur without warning while you are using this medicine, especially in older adults. Diclofenac can affect ovulation, and it may be harder to get pregnant while you are using this medicine.
Do not take extra medicine to make up the missed dose. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Avoid taking aspirin or other NSAIDs unless your doctor tells you to. Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms.
They may contain ingredients similar to diclofenac (such as aspirin, ibuprofen, ketoprofen, or naproxen). Get emergency medical help if you have signs of an allergic reaction to Voltaren (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Other drugs may interact with diclofenac, including prescription and over-the-counter medicines, vitamins, and herbal products. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Many people assume that if you rub a medication onto your skin it doesn’t go very far. That’s why there is little concern about side effects from gels or creams such as topical diclofenac.
Researchers have known for years that many medications can be absorbed through the skin and into the systemic circulation. They include nitroglycerin for the heart, fentanyl for pain, testosterone and estradiol for hormone replacement therapy, corticosteroids for inflammation and scopolamine for motion sickness.
“Topical NSAIDs provided good levels of pain relief in acute conditions such as sprains, strains and overuse injuries, probably similar to that provided by oral NSAIDs. I cannot use this drug, as it causes me severe stomach pain and acid reflux.
They cankillyou and are known to cause ulcers even when people are unaware of the damage until it is too late. Many people can apply topical NSAIDs without the complications associated with oral drugs like celecoxib, meloxicam or naproxen.
Even so, there are some individuals who are super sensitive to NSAIDs in general and topical diclofenac in particular. When I looked at the warnings (I cannot tolerate even tiny amounts of NSAIDs, due to other bad drug reactions that ruined my stomach) I asked about them.
I did fine on the samples, and paid $167 for a prescription for several big tubes of Voltaren. My stomach began to feel pretty awful in general.
It causes all the side effects of any oral NSAID, i.e., everything listed on the box as a warning was true. Brent reports a similar problem: “I tried the Voltaren gel because oral NSAIDs cause extreme stomach distress, acid reflux, and most frightening, atrial fibrillation.
If I only use a small amount, occasionally, the symptoms are mild, but it really doesn’t do much for relief.” For most people, occasional use of oral ibuprofen or naproxen is not highly dangerous.